Aging impairs double‐strand break repair by homologous recombination in Drosophila germ cells

Aging is characterized by genome instability, which contributes to cancer formation and cell lethality leading to organismal decline. The high levels of DNA double‐strand breaks (DSBs) observed in old cells and premature aging syndromes are likely a primary source of genome instability, but the unde...

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Publicat a:Aging Cell
Autors principals: Delabaere, Laetitia, Ertl, Henry A., Massey, Dashiell J., Hofley, Carolyn M., Sohail, Faraz, Bienenstock, Elisa J., Sebastian, Hans, Chiolo, Irene, LaRocque, Jeannine R.
Format: Artigo
Idioma:Inglês
Publicat: John Wiley and Sons Inc. 2016
Matèries:
Original Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5334535/
https://ncbi.nlm.nih.gov/pubmed/28000382
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.12556
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