Phenotypic characteristics of aged CD4(+) CD28(null) T lymphocytes are determined by changes in the whole‐genome DNA methylation pattern

Aging is associated with a progressive loss of the CD28 costimulatory molecule in CD4(+) lymphocytes (CD28(null) T cells), which is accompanied by the acquisition of new biological and functional properties that give rise to an impaired immune response. The regulatory mechanisms that govern the appe...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Aging Cell
Prif Awduron: Suarez‐Álvarez, Beatriz, Rodríguez, Ramón M., Schlangen, Karin, Raneros, Aroa Baragaño, Márquez‐Kisinousky, Leonardo, Fernández, Agustín F., Díaz‐Corte, Carmen, Aransay, Ana M., López‐Larrea, Carlos
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: John Wiley and Sons Inc. 2016
Pynciau:
Original Articles
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5334526/
https://ncbi.nlm.nih.gov/pubmed/28026094
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.12552
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