Phenotypic characteristics of aged CD4(+) CD28(null) T lymphocytes are determined by changes in the whole‐genome DNA methylation pattern

Aging is associated with a progressive loss of the CD28 costimulatory molecule in CD4(+) lymphocytes (CD28(null) T cells), which is accompanied by the acquisition of new biological and functional properties that give rise to an impaired immune response. The regulatory mechanisms that govern the appe...

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Publicado en:Aging Cell
Autores principales: Suarez‐Álvarez, Beatriz, Rodríguez, Ramón M., Schlangen, Karin, Raneros, Aroa Baragaño, Márquez‐Kisinousky, Leonardo, Fernández, Agustín F., Díaz‐Corte, Carmen, Aransay, Ana M., López‐Larrea, Carlos
Formato: Artigo
Lenguaje:Inglês
Publicado: John Wiley and Sons Inc. 2016
Materias:
Original Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5334526/
https://ncbi.nlm.nih.gov/pubmed/28026094
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.12552
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