Blockade of RyRs in the ER Attenuates 6-OHDA-Induced Calcium Overload, Cellular Hypo-Excitability and Apoptosis in Dopaminergic Neurons

Calcium (Ca(2+)) dyshomeostasis induced by endoplasmic reticulum (ER) stress is an important molecular mechanism of selective dopaminergic (DA) neuron loss in Parkinson’s disease (PD). Inositol 1,4,5-triphosphate receptors (IP(3)Rs) and ryanodine receptors (RyRs), which are located on the ER surface...

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Detalhes bibliográficos
Publicado no:Front Cell Neurosci
Main Authors: Huang, Lu, Xue, Ying, Feng, DaYun, Yang, RuiXin, Nie, Tiejian, Zhu, Gang, Tao, Kai, Gao, GuoDong, Yang, Qian
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2017
Assuntos:
Neuroscience
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5334509/
https://ncbi.nlm.nih.gov/pubmed/28316566
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fncel.2017.00052
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