Extrachromosomal oncogene amplification drives tumor evolution and genetic heterogeneity

Human cells have twenty-three pairs of chromosomes but in cancer, genes can be amplified in chromosomes or in circular extrachromosomal DNA (ECDNA), whose frequency and functional significance are not understood(1–4). We performed whole genome sequencing, structural modeling and cytogenetic analyses...

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Detalhes bibliográficos
Publicado no:Nature
Main Authors: Turner, Kristen M., Deshpande, Viraj, Beyter, Doruk, Koga, Tomoyuki, Rusert, Jessica, Lee, Catherine, Li, Bin, Arden, Karen, Ren, Bing, Nathanson, David A., Kornblum, Harley I., Taylor, Michael D., Kaushal, Sharmeela, Cavenee, Webster K., Wechsler-Reya, Robert, Furnari, Frank B., Vandenberg, Scott R., Rao, P. Nagesh, Wahl, Geoffrey M., Bafna, Vineet, Mischel, Paul S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5334176/
https://ncbi.nlm.nih.gov/pubmed/28178237
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature21356
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