Bile acids initiate cholestatic liver injury by triggering a hepatocyte-specific inflammatory response

Mechanisms of bile acid–induced (BA-induced) liver injury in cholestasis are controversial, limiting development of new therapies. We examined how BAs initiate liver injury using isolated liver cells from humans and mice and in-vivo mouse models. At pathophysiologic concentrations, BAs induced proin...

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Veröffentlicht in:JCI Insight
Hauptverfasser: Cai, Shi-Ying, Ouyang, Xinshou, Chen, Yonglin, Soroka, Carol J., Wang, Juxian, Mennone, Albert, Wang, Yucheng, Mehal, Wajahat Z., Jain, Dhanpat, Boyer, James L.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Clinical Investigation 2017
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5333973/
https://ncbi.nlm.nih.gov/pubmed/28289714
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.90780
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