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Preferential TNFα signaling via TNFR2 regulates epithelial injury and duct obstruction in experimental biliary atresia

Biliary atresia is an obstructive cholangiopathy of infancy that progresses to end-stage cirrhosis. Although the pathogenesis of the disease is not completely understood, previous reports link TNFα to apoptosis of the bile duct epithelium in the presence of IFNγ. Here, we investigate if TNFα signali...

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Bibliografiske detaljer
Udgivet i:JCI Insight
Main Authors: Shivakumar, Pranavkumar, Mizuochi, Tatsuki, Mourya, Reena, Gutta, Sridevi, Yang, Li, Luo, Zhenhua, Bezerra, Jorge A.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2017
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5333971/
https://ncbi.nlm.nih.gov/pubmed/28289704
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.88747
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