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Preferential TNFα signaling via TNFR2 regulates epithelial injury and duct obstruction in experimental biliary atresia
Biliary atresia is an obstructive cholangiopathy of infancy that progresses to end-stage cirrhosis. Although the pathogenesis of the disease is not completely understood, previous reports link TNFα to apoptosis of the bile duct epithelium in the presence of IFNγ. Here, we investigate if TNFα signali...
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| Gepubliceerd in: | JCI Insight |
|---|---|
| Hoofdauteurs: | , , , , , , |
| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
American Society for Clinical Investigation
2017
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5333971/ https://ncbi.nlm.nih.gov/pubmed/28289704 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.88747 |
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