Targeting adhesion signaling in KRAS, LKB1 mutant lung adenocarcinoma

Loss of LKB1 activity is prevalent in KRAS mutant lung adenocarcinoma and promotes aggressive and treatment-resistant tumors. Previous studies have shown that LKB1 is a negative regulator of the focal adhesion kinase (FAK), but in vivo studies testing the efficacy of FAK inhibition in LKB1 mutant ca...

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Udgivet i:JCI Insight
Main Authors: Gilbert-Ross, Melissa, Konen, Jessica, Koo, Junghui, Shupe, John, Robinson, Brian S., Wiles, Walter Guy, Huang, Chunzi, Martin, W. David, Behera, Madhusmita, Smith, Geoffrey H., Hill, Charles E., Rossi, Michael R., Sica, Gabriel L., Rupji, Manali, Chen, Zhengjia, Kowalski, Jeanne, Kasinski, Andrea L., Ramalingam, Suresh S., Fu, Haian, Khuri, Fadlo R., Zhou, Wei, Marcus, Adam I.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2017
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5333956/
https://ncbi.nlm.nih.gov/pubmed/28289710
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.90487
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