Targeting adhesion signaling in KRAS, LKB1 mutant lung adenocarcinoma

Loss of LKB1 activity is prevalent in KRAS mutant lung adenocarcinoma and promotes aggressive and treatment-resistant tumors. Previous studies have shown that LKB1 is a negative regulator of the focal adhesion kinase (FAK), but in vivo studies testing the efficacy of FAK inhibition in LKB1 mutant ca...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:JCI Insight
Päätekijät: Gilbert-Ross, Melissa, Konen, Jessica, Koo, Junghui, Shupe, John, Robinson, Brian S., Wiles, Walter Guy, Huang, Chunzi, Martin, W. David, Behera, Madhusmita, Smith, Geoffrey H., Hill, Charles E., Rossi, Michael R., Sica, Gabriel L., Rupji, Manali, Chen, Zhengjia, Kowalski, Jeanne, Kasinski, Andrea L., Ramalingam, Suresh S., Fu, Haian, Khuri, Fadlo R., Zhou, Wei, Marcus, Adam I.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Society for Clinical Investigation 2017
Aiheet:
Research Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC5333956/
https://ncbi.nlm.nih.gov/pubmed/28289710
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.90487
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