Targeting adhesion signaling in KRAS, LKB1 mutant lung adenocarcinoma

Loss of LKB1 activity is prevalent in KRAS mutant lung adenocarcinoma and promotes aggressive and treatment-resistant tumors. Previous studies have shown that LKB1 is a negative regulator of the focal adhesion kinase (FAK), but in vivo studies testing the efficacy of FAK inhibition in LKB1 mutant ca...

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Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:JCI Insight
Egile Nagusiak: Gilbert-Ross, Melissa, Konen, Jessica, Koo, Junghui, Shupe, John, Robinson, Brian S., Wiles, Walter Guy, Huang, Chunzi, Martin, W. David, Behera, Madhusmita, Smith, Geoffrey H., Hill, Charles E., Rossi, Michael R., Sica, Gabriel L., Rupji, Manali, Chen, Zhengjia, Kowalski, Jeanne, Kasinski, Andrea L., Ramalingam, Suresh S., Fu, Haian, Khuri, Fadlo R., Zhou, Wei, Marcus, Adam I.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Clinical Investigation 2017
Gaiak:
Research Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5333956/
https://ncbi.nlm.nih.gov/pubmed/28289710
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.90487
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