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Targeting adhesion signaling in KRAS, LKB1 mutant lung adenocarcinoma
Loss of LKB1 activity is prevalent in KRAS mutant lung adenocarcinoma and promotes aggressive and treatment-resistant tumors. Previous studies have shown that LKB1 is a negative regulator of the focal adhesion kinase (FAK), but in vivo studies testing the efficacy of FAK inhibition in LKB1 mutant ca...
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| Publicat a: | JCI Insight |
|---|---|
| Autors principals: | , , , , , , , , , , , , , , , , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
American Society for Clinical Investigation
2017
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5333956/ https://ncbi.nlm.nih.gov/pubmed/28289710 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.90487 |
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