Direct Keap1-Nrf2 disruption as a potential therapeutic target for Alzheimer’s disease

Nrf2, a transcriptional activator of cell protection genes, is an attractive therapeutic target for the prevention of neurodegenerative diseases, including Alzheimer’s disease (AD). Current Nrf2 activators, however, may exert toxicity and pathway over-activation can induce detrimental effects. An un...

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Detalhes bibliográficos
Publicado no:PLoS Genet
Main Authors: Kerr, Fiona, Sofola-Adesakin, Oyinkan, Ivanov, Dobril K., Gatliff, Jemma, Gomez Perez-Nievas, Beatriz, Bertrand, Hélène C., Martinez, Pedro, Callard, Rebecca, Snoeren, Inge, Cochemé, Helena M., Adcott, Jennifer, Khericha, Mobina, Castillo-Quan, Jorge Iván, Wells, Geoffrey, Noble, Wendy, Thornton, Janet, Partridge, Linda
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5333801/
https://ncbi.nlm.nih.gov/pubmed/28253260
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1006593
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