Scalable Design of Paired CRISPR Guide RNAs for Genomic Deletion

CRISPR-Cas9 technology can be used to engineer precise genomic deletions with pairs of single guide RNAs (sgRNAs). This approach has been widely adopted for diverse applications, from disease modelling of individual loci, to parallelized loss-of-function screens of thousands of regulatory elements....

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Bibliografiske detaljer
Udgivet i:PLoS Comput Biol
Main Authors: Pulido-Quetglas, Carlos, Aparicio-Prat, Estel, Arnan, Carme, Polidori, Taisia, Hermoso, Toni, Palumbo, Emilio, Ponomarenko, Julia, Guigo, Roderic, Johnson, Rory
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2017
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5333799/
https://ncbi.nlm.nih.gov/pubmed/28253259
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1005341
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