High-Sequence Diversity and Rapid Virus Turnover Contribute to Higher Rates of Coreceptor Switching in Treatment-Experienced Subjects with HIV-1 Viremia

Coreceptor switching from CCR5 to CXCR4 is common during chronic HIV-1 infection, but is even more common in individuals who have failed antiretroviral therapy (ART). Prior studies have suggested rapid mutation and/or recombination of HIV-1 envelope (env) genes during coreceptor switching. We compar...

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Bibliografski detalji
Izdano u:AIDS Res Hum Retroviruses
Glavni autori: Nedellec, Rebecca, Herbeck, Joshua T., Hunt, Peter W., Deeks, Steven G., Mullins, James I., Anton, Elizabeth D., Reeves, Jacqueline D., Mosier, Donald E.
Format: Artigo
Jezik:Inglês
Izdano: Mary Ann Liebert, Inc. 2017
Teme:
Pathogenesis
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5333564/
https://ncbi.nlm.nih.gov/pubmed/27604829
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/aid.2016.0153
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