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Human Immunodeficiency Virus Type 1 Coreceptor Switching: V1/V2 Gain-of-Fitness Mutations Compensate for V3 Loss-of-Fitness Mutations

Human immunodeficiency virus type 1 (HIV-1) entry into target cells is mediated by the virus envelope binding to CD4 and the conformationally altered envelope subsequently binding to one of two chemokine receptors. HIV-1 envelope glycoprotein (gp120) has five variable loops, of which three (V1/V2 an...

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Bibliografische gegevens
Hoofdauteurs: Pastore, C., Nedellec, R., Ramos, A., Pontow, S., Ratner, L., Mosier, D. E.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Microbiology 2006
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1346864/
https://ncbi.nlm.nih.gov/pubmed/16378977
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.80.2.750-758.2006
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