Amotl1 mediates sequestration of the Hippo effector Yap1 downstream of Fat4 to restrict heart growth

Although in flies the atypical cadherin Fat is an upstream regulator of Hippo signalling, the closest mammalian homologue, Fat4, has been shown to regulate tissue polarity rather than growth. Here we show in the mouse heart that Fat4 modulates Hippo signalling to restrict growth. Fat4 mutant myocard...

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Опубликовано в: :Nat Commun
Главные авторы: Ragni, Chiara V., Diguet, Nicolas, Le Garrec, Jean-François, Novotova, Marta, Resende, Tatiana P., Pop, Sorin, Charon, Nicolas, Guillemot, Laurent, Kitasato, Lisa, Badouel, Caroline, Dufour, Alexandre, Olivo-Marin, Jean-Christophe, Trouvé, Alain, McNeill, Helen, Meilhac, Sigolène M
Формат: Artigo
Язык:Inglês
Опубликовано: Nature Publishing Group 2017
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5333361/
https://ncbi.nlm.nih.gov/pubmed/28239148
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms14582
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