Amotl1 mediates sequestration of the Hippo effector Yap1 downstream of Fat4 to restrict heart growth

Although in flies the atypical cadherin Fat is an upstream regulator of Hippo signalling, the closest mammalian homologue, Fat4, has been shown to regulate tissue polarity rather than growth. Here we show in the mouse heart that Fat4 modulates Hippo signalling to restrict growth. Fat4 mutant myocard...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Ragni, Chiara V., Diguet, Nicolas, Le Garrec, Jean-François, Novotova, Marta, Resende, Tatiana P., Pop, Sorin, Charon, Nicolas, Guillemot, Laurent, Kitasato, Lisa, Badouel, Caroline, Dufour, Alexandre, Olivo-Marin, Jean-Christophe, Trouvé, Alain, McNeill, Helen, Meilhac, Sigolène M
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5333361/
https://ncbi.nlm.nih.gov/pubmed/28239148
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms14582
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