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Targeting MDM4 Splicing in Cancers
MDM4, an essential negative regulator of the P53 tumor suppressor, is frequently overexpressed in cancer cells that harbor a wild-type P53. By a mechanism based on alternative splicing, the MDM4 gene generates two mutually exclusive isoforms: MDM4-FL, which encodes the full-length MDM4 protein, and...
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| Publicado en: | Genes (Basel) |
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| Autores principales: | , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
MDPI
2017
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5333071/ https://ncbi.nlm.nih.gov/pubmed/28230750 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/genes8020082 |
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