The Function of FK506-Binding Protein 13 in Protein Quality Control Protects Plasma Cells from Endoplasmic Reticulum Stress-Associated Apoptosis

Plasma cells (PCs) are exposed to intense endoplasmic reticulum (ER) stress imposed by enormous rates of immunoglobulin (Ig) synthesis and secretion. Therefore, protein homeostasis is crucial for the survival of PCs, but its molecular mechanism remains largely unknown. Here, we found marked overexpr...

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Detalles Bibliográficos
Publicado en:Front Immunol
Autores principales: Jeong, Mini, Jang, Eunkyeong, Choi, Suk San, Ji, Changhoon, Lee, Kyungho, Youn, Jeehee
Formato: Artigo
Lenguaje:Inglês
Publicado: Frontiers Media S.A. 2017
Materias:
Immunology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5332356/
https://ncbi.nlm.nih.gov/pubmed/28303141
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2017.00222
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