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The Function of FK506-Binding Protein 13 in Protein Quality Control Protects Plasma Cells from Endoplasmic Reticulum Stress-Associated Apoptosis

Plasma cells (PCs) are exposed to intense endoplasmic reticulum (ER) stress imposed by enormous rates of immunoglobulin (Ig) synthesis and secretion. Therefore, protein homeostasis is crucial for the survival of PCs, but its molecular mechanism remains largely unknown. Here, we found marked overexpr...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Jeong, Mini, Jang, Eunkyeong, Choi, Suk San, Ji, Changhoon, Lee, Kyungho, Youn, Jeehee
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5332356/
https://ncbi.nlm.nih.gov/pubmed/28303141
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2017.00222
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