The action of β-hydroxybutyrate on the growth, metabolism and global histone H3 acetylation of spontaneous mouse mammary tumours: evidence of a β-hydroxybutyrate paradox

BACKGROUND: Ketone bodies have both metabolic and epigenetic roles in cancer. In several studies, they showed an anti-cancer effect via inhibition of histone deacetylases; however, other studies observed faster tumour growth. The related molecule butyrate also inhibits growth of some cancer cells an...

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Bibliographic Details
Published in:Cancer Metab
Main Authors: Rodrigues, Loreta M., Uribe-Lewis, Santiago, Madhu, Basetti, Honess, Davina J., Stubbs, Marion, Griffiths, John R.
Format: Artigo
Language:Inglês
Published: BioMed Central 2017
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Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5331634/
https://ncbi.nlm.nih.gov/pubmed/28261475
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40170-017-0166-z
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