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Dityromycin and GE82832 bind protein S12 and block EF-G catalyzed translocation
The translocation of messenger RNA and transfer RNA through the ribosome is catalyzed by EF-G, a universally conserved GTPase. The mechanism by which the closely related decapeptide antibiotics dityromycin and GE82832 inhibit EF-G-catalyzed translocation is elucidated in this study. Using crystallog...
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| Publicado no: | Cell Rep |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5331365/ https://ncbi.nlm.nih.gov/pubmed/24412368 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2013.12.024 |
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