Western diet induces colonic nitrergic myenteric neuropathy and dysmotility in mice via saturated fatty acid‐ and lipopolysaccharide‐induced TLR4 signalling

KEY POINTS: A high‐fat diet (60% kcal from fat) is associated with motility disorders inducing constipation and loss of nitrergic myenteric neurons in the proximal colon. Gut microbiota dysbiosis, which occurs in response to HFD, contributes to endotoxaemia. High levels of lipopolysaccharide lead to...

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Vydáno v:J Physiol
Hlavní autoři: Reichardt, François, Chassaing, Benoit, Nezami, Behtash Ghazi, Li, Ge, Tabatabavakili, Sahar, Mwangi, Simon, Uppal, Karan, Liang, Bill, Vijay‐Kumar, Matam, Jones, Dean, Gewirtz, Andrew T., Srinivasan, Shanthi
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley and Sons Inc. 2017
Témata:
Neuroscience ‐ neurobiology of disease
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5330876/
https://ncbi.nlm.nih.gov/pubmed/28000223
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/JP273269
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