Western diet induces colonic nitrergic myenteric neuropathy and dysmotility in mice via saturated fatty acid‐ and lipopolysaccharide‐induced TLR4 signalling

KEY POINTS: A high‐fat diet (60% kcal from fat) is associated with motility disorders inducing constipation and loss of nitrergic myenteric neurons in the proximal colon. Gut microbiota dysbiosis, which occurs in response to HFD, contributes to endotoxaemia. High levels of lipopolysaccharide lead to...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:J Physiol
Päätekijät: Reichardt, François, Chassaing, Benoit, Nezami, Behtash Ghazi, Li, Ge, Tabatabavakili, Sahar, Mwangi, Simon, Uppal, Karan, Liang, Bill, Vijay‐Kumar, Matam, Jones, Dean, Gewirtz, Andrew T., Srinivasan, Shanthi
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: John Wiley and Sons Inc. 2017
Aiheet:
Neuroscience ‐ neurobiology of disease
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC5330876/
https://ncbi.nlm.nih.gov/pubmed/28000223
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/JP273269
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