Western diet induces colonic nitrergic myenteric neuropathy and dysmotility in mice via saturated fatty acid‐ and lipopolysaccharide‐induced TLR4 signalling

KEY POINTS: A high‐fat diet (60% kcal from fat) is associated with motility disorders inducing constipation and loss of nitrergic myenteric neurons in the proximal colon. Gut microbiota dysbiosis, which occurs in response to HFD, contributes to endotoxaemia. High levels of lipopolysaccharide lead to...

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Bibliografiska uppgifter
I publikationen:J Physiol
Huvudupphovsmän: Reichardt, François, Chassaing, Benoit, Nezami, Behtash Ghazi, Li, Ge, Tabatabavakili, Sahar, Mwangi, Simon, Uppal, Karan, Liang, Bill, Vijay‐Kumar, Matam, Jones, Dean, Gewirtz, Andrew T., Srinivasan, Shanthi
Materialtyp: Artigo
Språk:Inglês
Publicerad: John Wiley and Sons Inc. 2017
Ämnen:
Neuroscience ‐ neurobiology of disease
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5330876/
https://ncbi.nlm.nih.gov/pubmed/28000223
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/JP273269
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