Western diet induces colonic nitrergic myenteric neuropathy and dysmotility in mice via saturated fatty acid‐ and lipopolysaccharide‐induced TLR4 signalling

KEY POINTS: A high‐fat diet (60% kcal from fat) is associated with motility disorders inducing constipation and loss of nitrergic myenteric neurons in the proximal colon. Gut microbiota dysbiosis, which occurs in response to HFD, contributes to endotoxaemia. High levels of lipopolysaccharide lead to...

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Detalhes bibliográficos
Publicado no:J Physiol
Main Authors: Reichardt, François, Chassaing, Benoit, Nezami, Behtash Ghazi, Li, Ge, Tabatabavakili, Sahar, Mwangi, Simon, Uppal, Karan, Liang, Bill, Vijay‐Kumar, Matam, Jones, Dean, Gewirtz, Andrew T., Srinivasan, Shanthi
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2017
Assuntos:
Neuroscience ‐ neurobiology of disease
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5330876/
https://ncbi.nlm.nih.gov/pubmed/28000223
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/JP273269
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