Western diet induces colonic nitrergic myenteric neuropathy and dysmotility in mice via saturated fatty acid‐ and lipopolysaccharide‐induced TLR4 signalling

KEY POINTS: A high‐fat diet (60% kcal from fat) is associated with motility disorders inducing constipation and loss of nitrergic myenteric neurons in the proximal colon. Gut microbiota dysbiosis, which occurs in response to HFD, contributes to endotoxaemia. High levels of lipopolysaccharide lead to...

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Bibliographic Details
Published in:J Physiol
Main Authors: Reichardt, François, Chassaing, Benoit, Nezami, Behtash Ghazi, Li, Ge, Tabatabavakili, Sahar, Mwangi, Simon, Uppal, Karan, Liang, Bill, Vijay‐Kumar, Matam, Jones, Dean, Gewirtz, Andrew T., Srinivasan, Shanthi
Format: Artigo
Language:Inglês
Published: John Wiley and Sons Inc. 2017
Subjects:
Neuroscience ‐ neurobiology of disease
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5330876/
https://ncbi.nlm.nih.gov/pubmed/28000223
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/JP273269
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