Post‐translational cleavage of Hv1 in human sperm tunes pH‐ and voltage‐dependent gating

KEY POINTS: In human sperm, proton flux across the membrane is controlled by the voltage‐gated proton channel Hv1. We show that sperm harbour both Hv1 and an N‐terminally cleaved isoform termed Hv1Sper. The pH‐control of Hv1Sper and Hv1 is distinctively different. Hv1Sper and Hv1 can form heterodime...

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Vydáno v:J Physiol
Hlavní autoři: Berger, Thomas K., Fußhöller, David M., Goodwin, Normann, Bönigk, Wolfgang, Müller, Astrid, Dokani Khesroshahi, Nasim, Brenker, Christoph, Wachten, Dagmar, Krause, Eberhard, Kaupp, U. Benjamin, Strünker, Timo
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley and Sons Inc. 2017
Témata:
Molecular and Cellular
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5330862/
https://ncbi.nlm.nih.gov/pubmed/27859356
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/JP273189
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