Design of T cell receptor libraries with diverse binding properties to examine adoptive T cell responses

Adoptive T cell therapies have shown significant promise in the treatment of cancer and viral diseases. One approach, that introduces antigen-specific T cell receptors (TCRs) into ex vivo activated T cells, is designed to overcome central tolerance mechanisms that prevent responses by endogenous T c...

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Bibliografiska uppgifter
I publikationen:Gene Ther
Huvudupphovsmän: Chervin, A.S., Stone, J.D., Soto, C.M., Engels, B., Schreiber, H., Roy, E.J., Kranz, D.M.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2012
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5330764/
https://ncbi.nlm.nih.gov/pubmed/23052828
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/gt.2012.80
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