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Mitochondrial biogenesis and proteome remodeling promotes one carbon metabolism for T cell activation

Naïve T cell stimulation activates anabolic metabolism to fuel the transition from quiescence to growth and proliferation. Here we show that naïve CD4(+) T cell activation induces a unique program of mitochondrial biogenesis and remodeling. Using mass spectrometry, we quantified protein dynamics dur...

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書誌詳細
出版年:Cell Metab
主要な著者: Ron-Harel, Noga, Santos, Daniel, Ghergurovich, Jonathan M., Sage, Peter T., Reddy, Anita, Lovitch, Scott B., Dephoure, Noah, Satterstrom, F. Kyle, Sheffer, Michal, Spinelli, Jessica B., Gygi, Steven, Rabinowitz, Joshua D., Sharpe, Arlene H., Haigis, Marcia C.
フォーマット: Artigo
言語:Inglês
出版事項: 2016
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC5330619/
https://ncbi.nlm.nih.gov/pubmed/27411012
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2016.06.007
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