Suppression by T(FR) cells leads to durable and selective inhibition of B cell effector functions

T follicular regulatory (T(FR)) cells inhibit T follicular helper (T(FH)) cell-mediated antibody production. The mechanisms by which T(FR) cells exert their key immunoregulatory functions are largely unknown. Here we show that T(FR) cells induce a distinct suppressive state in T(FH) and B cells, in...

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Detalhes bibliográficos
Publicado no:Nat Immunol
Main Authors: Sage, Peter T., Ron-Harel, Noga, Juneja, Vikram R., Sen, Debattama R., Maleri, Seth, Sungnak, Waradon, Kuchroo, Vijay K., Haining, W. Nicholas, Chevrier, Nicolas, Haigis, Marcia, Sharpe, Arlene H.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5502675/
https://ncbi.nlm.nih.gov/pubmed/27695002
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.3578
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