Crosstalk between PKCζ and the IL4/Stat6 pathway during T-cell-mediated hepatitis

PKCζ is required for nuclear factor κ-B (NF-κB) activation in several cell systems. NF-κB is a suppressor of liver apoptosis during development and in concanavalin A (ConA)-induced T-cell-mediated hepatitis. Here we show that PKCζ−/− mice display inhibited ConA-induced NF-κB activation and reduced d...

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Main Authors: Durán, Angeles, Rodriguez, Angelina, Martin, Pilar, Serrano, Manuel, Flores, Juana Maria, Leitges, Michael, Diaz-Meco, María T, Moscat, Jorge
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2004
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC533053/
https://ncbi.nlm.nih.gov/pubmed/15526032
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7600468
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