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Crosstalk between PKCζ and the IL4/Stat6 pathway during T-cell-mediated hepatitis
PKCζ is required for nuclear factor κ-B (NF-κB) activation in several cell systems. NF-κB is a suppressor of liver apoptosis during development and in concanavalin A (ConA)-induced T-cell-mediated hepatitis. Here we show that PKCζ−/− mice display inhibited ConA-induced NF-κB activation and reduced d...
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| Autors principals: | , , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Nature Publishing Group
2004
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC533053/ https://ncbi.nlm.nih.gov/pubmed/15526032 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7600468 |
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