Combinatory antibiotic therapy increases rate of bacterial kill but not final outcome in a novel mouse model of Staphylococcus aureus spinal implant infection

BACKGROUND: Management of spine implant infections (SII) are challenging. Explantation of infected spinal hardware can destabilize the spine, but retention can lead to cord compromise and biofilm formation, complicating management. While vancomycin monotherapy is commonly used, in vitro studies have...

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Publicado en:PLoS One
Autores principales: Hu, Yan, Hegde, Vishal, Johansen, Daniel, Loftin, Amanda H., Dworsky, Erik, Zoller, Stephen D., Park, Howard Y., Hamad, Christopher D., Nelson, George E., Francis, Kevin P., Scaduto, Anthony, Bernthal, Nicholas M.
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5330510/
https://ncbi.nlm.nih.gov/pubmed/28245229
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0173019
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