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Insulin signaling regulates a functional interaction between adenomatous polyposis coli and cytoplasmic dynein

Diabetes is linked to an increased risk for colorectal cancer, but the mechanistic underpinnings of this clinically important effect are unclear. Here we describe an interaction between the microtubule motor cytoplasmic dynein, the adenomatous polyposis coli tumor suppressor protein (APC), and glyco...

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Veröffentlicht in:Mol Biol Cell
Hauptverfasser: Gao, Feng J., Shi, Liang, Hines, Timothy, Hebbar, Sachin, Neufeld, Kristi L., Smith, Deanna S.
Format: Artigo
Sprache:Inglês
Veröffentlicht: The American Society for Cell Biology 2017
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5328618/
https://ncbi.nlm.nih.gov/pubmed/28057765
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E16-07-0555
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