Synthesis and Evaluation of Chirally Defined Side Chain Variants of 7-Chloro-4-Aminoquinoline To Overcome Drug Resistance in Malaria Chemotherapy

A novel 4-aminoquinoline derivative [(S)-7-chloro-N-(4-methyl-1-(4-methylpiperazin-1-yl)pentan-2-yl)-quinolin-4-amine triphosphate] exhibiting curative activity against chloroquine-resistant malaria parasites has been identified for preclinical development as a blood schizonticidal agent. The lead m...

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Vydáno v:Antimicrob Agents Chemother
Hlavní autoři: Dola, Vasantha Rao, Soni, Awakash, Agarwal, Pooja, Ahmad, Hafsa, Raju, Kanumuri Siva Rama, Rashid, Mamunur, Wahajuddin, Muhammad, Srivastava, Kumkum, Haq, W., Dwivedi, A. K., Puri, S. K., Katti, S. B.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2017
Témata:
Chemistry; Biosynthesis
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5328577/
https://ncbi.nlm.nih.gov/pubmed/27956423
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01152-16
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