Synthesis and Antimalarial Activity of 3,3-Spiroanellated 5,6-Disubstituted 1,2,4-Trioxanes

[Image: see text] Novel 3,3-spiroanellated 5-aryl, 6-arylvinyl-substituted 1,2,4-trioxanes 19–34 have been synthesized and appraised for their antimalarial activity against multidrug-resistant Plasmodium yoelii nigeriensis in Swiss mice by oral route at doses ranging from 96 mg/kg × 4 days to 24 mg/...

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Detalhes bibliográficos
Main Authors: Maurya, Ranjani, Soni, Awakash, Anand, Devireddy, Ravi, Makthala, Raju, Kanumuri S. R., Taneja, Isha, Naikade, Niraj K., Puri, S. K., Wahajuddin, Kanojiya, Sanjeev, Yadav, Prem P.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2012
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4027577/
https://ncbi.nlm.nih.gov/pubmed/24900640
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml300188t
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