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Electronically stabilized versions of the antimalarial acetal trioxanes artemether and artesunate
[Image: see text] From 9-substituted DHA, several new artemisinin-derived C-10 acetal ethers and esters were prepared with either a 9-fluoro or a 9-sulfonyl substituent. The very strong inductive electron-withdrawing C-9 substituent is shown to retard considerably C-10 ionization (acid-promoted ethe...
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| Main Authors: | , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
2008
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2668193/ https://ncbi.nlm.nih.gov/pubmed/18353653 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2008.03.010 |
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