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Nephrotoxicity of Polymyxins: Is There Any Difference between Colistimethate and Polymyxin B?

Nephrotoxicity is a common adverse effect of the clinically used polymyxins, colistin and polymyxin B. This adverse effect is dose limiting for both polymyxins, as the plasma polymyxin concentrations associated with renal damage overlap those required for antibacterial effect. Since development of a...

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Pubblicato in:Antimicrob Agents Chemother
Autori principali: Zavascki, Alexandre P., Nation, Roger L.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2017
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5328560/
https://ncbi.nlm.nih.gov/pubmed/27993859
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02319-16
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