Pharmacological Blockade of the Chemokine Receptor CCR1 Protects Mice from Systemic Candidiasis of Hematogenous Origin

Systemic candidiasis is a leading cause of nosocomial bloodstream infection with a high mortality rate despite treatment. Immune-based strategies are needed to improve outcomes. We previously reported that genetic deficiency in the chemokine receptor CCR1 improves survival and ameliorates tissue dam...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: Lionakis, Michail S., Albert, Nathaniel D., Swamydas, Muthulekha, Lee, Chyi-Chia R., Loetscher, Pius, Kontoyiannis, Dimitrios P.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2017
Assuntos:
Experimental Therapeutics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5328547/
https://ncbi.nlm.nih.gov/pubmed/27993850
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02365-16
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