High-Dose Ampicillin-Sulbactam Combinations Combat Polymyxin-Resistant Acinetobacter baumannii in a Hollow-Fiber Infection Model

Acinetobacter baumannii is emerging with resistance to polymyxins. In 24-h time-kill experiments, high-dose ampicillin-sulbactam in combination with meropenem and polymyxin B achieved additivity or synergy against 10(8) CFU/ml of two clinical A. baumannii isolates resistant to all three drugs (maxim...

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Bibliografiske detaljer
Udgivet i:Antimicrob Agents Chemother
Main Authors: Lenhard, Justin R., Smith, Nicholas M., Bulman, Zackery P., Tao, Xun, Thamlikitkul, Visanu, Shin, Beom S., Nation, Roger L., Li, Jian, Bulitta, Jürgen B., Tsuji, Brian T.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2017
Fag:
Pharmacology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5328540/
https://ncbi.nlm.nih.gov/pubmed/28052852
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01268-16
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