Differential Macrophage Polarization from Pneumocystis in Immunocompetent and Immunosuppressed Hosts: Potential Adjunctive Therapy during Pneumonia

We explored differential polarization of macrophages during infection using a rat model of Pneumocystis pneumonia. We observed enhanced pulmonary M1 macrophage polarization in immunosuppressed (IS) hosts, but an M2 predominant response in immunocompetent (IC) hosts following Pneumocystis carinii cha...

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Dades bibliogràfiques
Publicat a:Infect Immun
Autors principals: Nandakumar, Vijayalakshmi, Hebrink, Deanne, Jenson, Paige, Kottom, Theodore, Limper, Andrew H.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2017
Matèries:
Fungal and Parasitic Infections
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5328482/
https://ncbi.nlm.nih.gov/pubmed/27993972
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.00939-16
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