Genetic variants alter T-bet binding and gene expression in mucosal inflammatory disease

The polarization of CD4+ T cells into distinct T helper cell lineages is essential for protective immunity against infection, but aberrant T cell polarization can cause autoimmunity. The transcription factor T-bet (TBX21) specifies the Th1 lineage and represses alternative T cell fates. Genome-wide...

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Detalhes bibliográficos
Publicado no:PLoS Genet
Main Authors: Soderquest, Katrina, Hertweck, Arnulf, Giambartolomei, Claudia, Henderson, Stephen, Mohamed, Rami, Goldberg, Rimma, Perucha, Esperanza, Franke, Lude, Herrero, Javier, Plagnol, Vincent, Jenner, Richard G., Lord, Graham M.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5328407/
https://ncbi.nlm.nih.gov/pubmed/28187197
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1006587
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