T-bet Activates Th1 Genes through Mediator and the Super Elongation Complex

The transcription factor T-bet directs Th1 cell differentiation, but the molecular mechanisms that underlie this lineage-specific gene regulation are not completely understood. Here, we show that T-bet acts through enhancers to allow the recruitment of Mediator and P-TEFb in the form of the super el...

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Detalhes bibliográficos
Publicado no:Cell Rep
Main Authors: Hertweck, Arnulf, Evans, Catherine M., Eskandarpour, Malihe, Lau, Jonathan C.H., Oleinika, Kristine, Jackson, Ian, Kelly, Audrey, Ambrose, John, Adamson, Peter, Cousins, David J., Lavender, Paul, Calder, Virginia L., Lord, Graham M., Jenner, Richard G.
Formato: Artigo
Idioma:Inglês
Publicado em: Cell Press 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4920892/
https://ncbi.nlm.nih.gov/pubmed/27292648
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2016.05.054
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