T-bet Activates Th1 Genes through Mediator and the Super Elongation Complex

The transcription factor T-bet directs Th1 cell differentiation, but the molecular mechanisms that underlie this lineage-specific gene regulation are not completely understood. Here, we show that T-bet acts through enhancers to allow the recruitment of Mediator and P-TEFb in the form of the super el...

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Bibliografske podrobnosti
izdano v:Cell Rep
Main Authors: Hertweck, Arnulf, Evans, Catherine M., Eskandarpour, Malihe, Lau, Jonathan C.H., Oleinika, Kristine, Jackson, Ian, Kelly, Audrey, Ambrose, John, Adamson, Peter, Cousins, David J., Lavender, Paul, Calder, Virginia L., Lord, Graham M., Jenner, Richard G.
Format: Artigo
Jezik:Inglês
Izdano: Cell Press 2016
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4920892/
https://ncbi.nlm.nih.gov/pubmed/27292648
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2016.05.054
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