GWAS for serum galactose-deficient IgA1 implicates critical genes of the O-glycosylation pathway

Aberrant O-glycosylation of serum immunoglobulin A1 (IgA1) represents a heritable pathogenic defect in IgA nephropathy, the most common form of glomerulonephritis worldwide, but specific genetic factors involved in its determination are not known. We performed a quantitative GWAS for serum levels of...

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Vydáno v:PLoS Genet
Hlavní autoři: Kiryluk, Krzysztof, Li, Yifu, Moldoveanu, Zina, Suzuki, Hitoshi, Reily, Colin, Hou, Ping, Xie, Jingyuan, Mladkova, Nikol, Prakash, Sindhuri, Fischman, Clara, Shapiro, Samantha, LeDesma, Robert A., Bradbury, Drew, Ionita-Laza, Iuliana, Eitner, Frank, Rauen, Thomas, Maillard, Nicolas, Berthoux, Francois, Floege, Jürgen, Chen, Nan, Zhang, Hong, Scolari, Francesco, Wyatt, Robert J., Julian, Bruce A., Gharavi, Ali G., Novak, Jan
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2017
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5328405/
https://ncbi.nlm.nih.gov/pubmed/28187132
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1006609
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