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Co-localization between Sequence Constraint and Epigenomic Information Improves Interpretation of Whole-Genome Sequencing Data

The identification of functional regions in the noncoding human genome is difficult but critical in order to gain understanding of the role noncoding variation plays in gene regulation in human health and disease. We describe here a co-localization approach that aims to identify constrained sequence...

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Bibliographic Details
Published in:Am J Hum Genet
Main Authors: Xu, Danqing, Wang, Chen, Kiryluk, Krzysztof, Buxbaum, Joseph D., Ionita-Laza, Iuliana
Format: Artigo
Language:Inglês
Published: Elsevier 2020
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7118583/
https://ncbi.nlm.nih.gov/pubmed/32243819
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajhg.2020.03.003
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