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BCR and Endosomal TLR Signals Synergize to Increase AID Expression and Establish Central B Cell Tolerance
Activation-induced cytidine deaminase (AID) is required to purge autoreactive immature and transitional-1 (immature/T1) B cells at the first tolerance checkpoint but how AID selectively removes self-reactive B cells is unclear. We now show that B cell antigen receptor (BCR) and endosomal Toll-like r...
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| Publicado en: | Cell Rep |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2017
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5328188/ https://ncbi.nlm.nih.gov/pubmed/28199836 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2017.01.050 |
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