The Development of Rapastinel (Formerly GLYX-13); A Rapid Acting and Long Lasting Antidepressant

BACKGROUND: Rapastinel (GLYX-13) is a NMDA receptor modulator with glycine-site partial agonist properties. It is a robust cognitive enhancer and shows rapid and long-lasting antidepressant properties in both animal models and in humans. METHODS: Rapastinel was derived from a monoclonal antibody, B6...

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Pubblicato in:Curr Neuropharmacol
Autori principali: Moskal, Joseph R., Burgdorf, Jeffrey S., Stanton, Patric K., Kroes, Roger A., Disterhoft, John F., Burch, Ronald M., Khan, M. Amin
Natura: Artigo
Lingua:Inglês
Pubblicazione: Bentham Science Publishers 2017
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5327451/
https://ncbi.nlm.nih.gov/pubmed/26997507
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2174/1570159X14666160321122703
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