An M2-V27A channel blocker demonstrates potent in vitro and in vivo antiviral activities against amantadine-sensitive and -resistant influenza A viruses

Adamantanes such as amantadine (1) and rimantadine (2) are FDA-approved anti-influenza drugs that act by inhibiting the wild-type M2 proton channel from influenza A viruses, thereby inhibiting the uncoating of the virus. Although adamantanes have been successfully used for more than four decades, th...

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Veröffentlicht in:Antiviral Res
Hauptverfasser: Hu, Yanmei, Musharrafieh, Rami, Ma, Chunlong, Zhang, Jiantao, Smee, Donald F., DeGrado, William F., Wang, Jun
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2017
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5326599/
https://ncbi.nlm.nih.gov/pubmed/28087313
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.antiviral.2017.01.006
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