Paradoxical antidepressant effects of alcohol are related to acid sphingomyelinase and its control of sphingolipid homeostasis

Alcohol is a widely consumed drug that can lead to addiction and severe brain damage. However, alcohol is also used as self-medication for psychiatric problems, such as depression, frequently resulting in depression-alcoholism comorbidity. Here, we identify the first molecular mechanism for alcohol...

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Detalhes bibliográficos
Publicado no:Acta Neuropathol
Main Authors: Müller, Christian P., Kalinichenko, Liubov S., Tiesel, Jens, Witt, Matthias, Stöckl, Thomas, Sprenger, Eva, Fuchser, Jens, Beckmann, Janine, Praetner, Marc, Huber, Sabine E., Amato, Davide, Mühle, Christiane, Büttner, Christian, Ekici, Arif B., Smaga, Irena, Pomierny-Chamiolo, Lucyna, Pomierny, Bartosz, Filip, Malgorzata, Eulenburg, Volker, Gulbins, Erich, Lourdusamy, Anbarasu, Reichel, Martin, Kornhuber, Johannes
Formato: Artigo
Idioma:Inglês
Publicado em: Springer Berlin Heidelberg 2016
Assuntos:
Original Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5325869/
https://ncbi.nlm.nih.gov/pubmed/28000031
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00401-016-1658-6
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