PARP3 controls TGFβ and ROS driven epithelial-to-mesenchymal transition and stemness by stimulating a TG2-Snail-E-cadherin axis

Several members of the Poly(ADP-ribose) polymerase (PARP) family are essential regulators of genome integrity, actively prospected as drug targets for cancer therapy. Among them, PARP3 is well characterized for its functions in double-strand break repair and mitotis. Here we report that PARP3 also p...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Karicheva, Olga, Rodriguez-Vargas, José Manuel, Wadier, Nadège, Martin-Hernandez, Kathline, Vauchelles, Romain, Magroun, Najat, Tissier, Agnès, Schreiber, Valérie, Dantzer, Françoise
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2016
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5325429/
https://ncbi.nlm.nih.gov/pubmed/27579892
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.11627
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