Hypoxia inducible factor-1 mediates the expression of the immune checkpoint HLA-G in glioma cells through hypoxia response element located in exon 2

HLA-G is an immune checkpoint molecule with specific relevance in cancer immunotherapy. It was first identified in cytotrophoblasts, protecting the fetus from maternal rejection. HLA-G tissue expression is very restricted but induced in numerous malignant tumors such as glioblastoma, contributing to...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Yaghi, Layale, Poras, Isabelle, Simoes, Renata T., Donadi, Eduardo A., Tost, Jörg, Daunay, Antoine, de Almeida, Bibiana Sgorla, Carosella, Edgardo D., Moreau, Philippe
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2016
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Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5325396/
https://ncbi.nlm.nih.gov/pubmed/27577073
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.11628
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